New Caledonia has an unusual linguistic dynamic in comparison to other French overseas territories.While New Caledonia was established as a penal colony in 1853, the other French islands were settled as plantation colonies in the 17th and 18th centuries.In these areas, French Creole is usually the lingua franca and has lower status than French.In N
Investigating the effect of prescribing status and patient characteristics on the therapeutic outcomes in patients with diabetes using a leftover drug adjustment protocol
Treatment for diabetes includes anti-diabetic medication in addition to lifestyle improvements through diet and exercise.In Japan, protocol-based Butter Dishes pharmacotherapy management allows drug treatment to be provided through cooperation between physicians and pharmacists, based on a protocol that is prepared and agreed upon in advance.Howeve
Expression and Function of Transmembrane-4 Superfamily (Tetraspanin) Proteins in Osteoclasts: Reciprocal Roles of Tspan-5 and NET-6 during Osteoclastogenesis
Background: Osteoclasts are bone-resorbing multinuclear polykaryons essential for bone remodeling, formed through cell fusion of mononuclear macrophage/monocyte lineage precursor cells upon stimulation by the RANK/RANKL system.Recent studies have revealed that a family of tetraspanin proteins, such as CD9, is critically involved in the cell fusion/
Spatial Distribution and Predictive Significance of Dendritic Cells and Macrophages in Esophageal Cancer Treated With Combined Chemoradiotherapy and PD-1 Blockade
BackgroundThe first clinical study (NCT03671265) of first-line chemoradiotherapy combined with PD-1 blockade Garments showed promising treatment outcomes in locally advanced esophageal squamous cell carcinoma (ESCC).However, partial patients did not respond to the combination treatment.The roles of dendritic cells (DCs) and macrophages in this comb
CTST: CNN and Transformer-Based Spatio-Temporally Synchronized Network for Remote Sensing Change Detection
Remote sensing change detection has achieved amazing results in recent years, especially the application of convolutional neural networks (CNN) and Transformer networks, which have revolutionized Pattern the field.However, the complex ground cover changes and the differences in lighting conditions caused by different times still pose challenges to